FPDP-D and DDGS Theses 1999-2015

The alpha2C-adrenoceptor as a neuropsychiatric drug target – PET studies in human subjects 11.12.2015 Jussi Lehto, University of Turku
Supervised by Professor Mika Scheinin
Opponent: Docent Tapani Keränen

Natural Born Weight Gainers – The Mechanisms of Obesity in Transgenic Mice Overexpressing Neuropeptide Y 30.10.2015 M.Sc Laura Vähätalo, University of Turku
Supervised by Docent Eriika Savontaus and PhD Suvi Ruohonen
Opponent: Docent T. Petteri Piepponen

GABAA receptor subunit-related neuroanatomical substrates for attenuation of anxiety 30.10.2015 M.Sc Kati S. Hellsten, University of Helsinki
Supervised by Professor Esa Korpi
Opponent: Docent Irma Holopainen

Progesterone Target Genes in Breast Cancer Cells 30.10.2015
M.Sc Sami Purmonen, University of Tampere
Supervised by Professor Timo Ylikomi
Opponent: Professor Sari Mäkelä

Individualized chemical systems medicine of acute and chronic myeloid leukemia 20.10.2015 MSc Tea Pemovska, University of Helsinki
Supervised by FIMM-EMBL Group Leader Krister Wennerberg (FIMM, University of Helsinki) and Prof. Kimmo Porkka (Helsinki University Hospital Comprehensive Cancer Center).
Opponent: Associate Professor Neil P. Shah, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

Translational models of coronary artery disease, myocardial infarction and heart failure. Development, validation and in vivo imaging studies using positron emission tomography 29.5.2015 MSc Miikka Tarkia, University of Turku
Supervised by professor Anne Roivainen, professor Antti Saraste, University of Turku
Opponent: Professor Johanna Kuusisto, University of Eastern Finland

Regulation of hepatic glucose homeostasis and Cytochrome P450 enzymes by energy-sensing coactivator PGC-1α
22.5.2015 MSc Sanna-Mari Aatsinki University of Oulu
Supervised by Professor Jukka Hakkola, University of Oulu
Opponent: Docent Eriika Savontaus, Department of Pharmacology, Drug Development and Therapeutics, University of Turku.

To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis 27.3.2015 MSc Jenni Mäki-Jouppila University of Turku
Supervised by Docent Marko Kallio (Department of Physiology, University of Turku)
Opponent: PhD Jakob Nilsson, University of Copenhagen

Behavioral and Pharmacological Characterization of a Mouse Model for Psychotic Disorders – Focus on Glutamatergic Transmission 16.1.2015 MSc Milica Maksimovic Supervised by Esa Korpi, Department of Pharmacology, Neuropharmacology, University of Helsinki
Opponent: Docent Eriika Savontaus, Department of Pharmacology, Drug Development and Therapeutics, University of Turku.

α- AND γ-MELANOCYTE STIMULATING HORMONES IN OBESITY A study of the key central areas of metabolic regulation 19.09.2014 M.Sc. Kim Eerola Supervised by Eriika Savontaus, Mikko Savontaus (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Opponent: Professor Atso Raasmaja, University of Helsinki

Mitogen-activated Protein Kinase Phosphatases in Inflammation and as Anti-inflammatory Drug Targets 29.8.2014 M.Sc. (Pharm) Tuija Hömmö Supervised by Associate professor Riku Korhonen and Professor Eeva Moilanen, Pharmacology and Clinical Pharmacology, University of Tampere
Opponent: Professor Ullamari Pesonen, University of Turku

Cell model systems in characterizing alpha2-adrenoceptors as drug targets 30.5.2014 M.Sc. Susann Björk Supervised by Professor Mika Scheinin (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Opponent: Associate Professor Gunnar Schulte, Karolinska Institutet, Stockholm, Sweden

Phospholipase Cascades in OX1 Orexin Receptor Signaling 23.5.2014 M.Sc. Maria Jäntti (Faculty of Veterinary Medicine, University of Helsinki). Supervised by Professor Jyrki Kukkonen (University of Helsinki).
Opponent: Associate professor Harpal Randeva, University of Warwick

Molecular Determinants of Orexin Receptor-Ligand Interaction: Studies on Ligand Selectivity and Impact of Calcium 14.2.2014 Jaana Putula (Faculty of Veterinary Medicine, University of Helsinki). Supervised by Professor Jyrki Kukkonen (University of Helsinki)

Virtual screening: Development of a novel structure-based method 24.8.2013, Salla Virtanen, Unioversity of Jyväskylä, Supervised by Professor Olli Pentikäinen, University of Jyväskylä).

MicroRNAs as novel regulators of skeletal homeostasis, 8.3.2013, Salla Laine,(Department of Cell Biology and Anatomy, University of Turku)
Supervised by Docent Tiina Laitala-Leinonen (Department of Cell Biology and Anatomy, University of Turku).

Identification of epigenetic targets in prostate cancer for therapeutic development, 1.3.2013, Mari Björkman, (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Matias Nees, VTT Medical Biotechnology and Turku Centre for Biotechnology, University of Turku and Professor Olli Kallioniemi (Institute for Molecular Medicine, FIMM, University of Helsinki).

JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
11.2.2013, Artur Padzik (Turku Centre for Biotechnology, Åbo Akademi University and University of Turku).
Supervised by Docent Eleanor Coffey (Turku Centre for Biotechnology, Åbo Akademi University and University of Turku).

18F-Radiolabeled porous silicon particles for drug delivery – Tracer development and evaluation in rats 11.1.2013 Mirkka Sarparanta (University of Helsinki, Faculty of Science, Department of Chemistry, Laboratory of Radiochemistry).
Supervised by Docent Anu Airaksinen (University of Helsinki, Faculty of Science, Department of Chemistry, Laboratory of Radiochemistry).

New Perspectives on the Melanocortins and Their Cardiovascular Effects – Potential Implications for the Treatment of Cardiovascular Diseases with Melanocortin Analogues 11.1.2013 Petteri Rinne (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Eriika Savontaus (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Regulation of murine hepatic Cytochrome P450 2a5 expression by transcription factor Nuclear factor (erythroid-derived 2)-like 2 19.10.2012 Virpi Lämsä (University of Oulu, Department of Pharmacology and Toxicology). Supervised by Professor Jukka Hakkola (University of Oulu, Department of Pharmacology and Toxicology).

Bacterium – host cell interactions in Chlamydia pneumoniae infection: the bacterial invasion and intracellular growth 5.10.2012 Juha Korhonen
(Turku Centre for Biotechnology). Supervised by Professor Riitta Lahesmaa (Turku Centre for Biotechnology).

Detection of the Vulnerable Atherosclerotic Plaques. Pre-Clinical Evaluation of Novel PET Imaging Probes with Experimental Models 5.10.2012 Johanna Silvola (Turku PET Centre). Supervised by Adjunct Professor Anne Roivainen (Turku PET Centre and Turku Centre for Disease Modelling)

Studies on OX1 Orexin Receptor Coupling to Arachidonic Acid and Endocannabinoid Signaling 23.8.2012 Pauli Turunen (University of Helsinki, Faculty of Veterinary Medicine).
Supervised by Professor Jyrki Kukkonen (University of Helsinki, Faculty of Veterinary Medicine).

Dissecting the molecular mechanisms of breast cancer bone metastasis for therapeutic targeting 13.4.2012 Sirkku Pollari
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Professor Olli Kallioniemi (Institute for Molecular Medicine, FIMM, University of Helsinki)

In vivo imaging of vascular adhesion protein 1 – preclinical studies with positron emission tomography 31.3.2012 Anu Autio (Turku PET Centre, University of Turku)
Supervised by Professor Anne Roivainen (Turku PET Centre and Turku Centre for Disease Modelling, University of Turku).

Chemical Biology Screen for Prostate Cancer Therapeutics
16.12.2011, by Kirsi Ketola,
(Department of Biochemistry and Food Chemistry, University of Turku; Turku Centre for Biotechnology; Medical Biotechnology, VTT Technical Research Centre of Finland).
Supervised by Professor Johanna Ivaska (Department of BiochemistrySupervised by Docent Kristiina Iljin (VTT Medical Biotechnology and Turku Centre for Biotechnology) and Professor Olli Kallioniemi (Institute for Molecular Medicine, FIMM, University of Helsinki).

High-Throughput Screening for Novel Prostate Cancer Drug Targets –Getting Personal
25.11.2011, by Paula Vainio,
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Kristiina Iljin (VTT Medical Biotechnology and Turku Centre for Biotechnology) and Professor Olli Kallioniemi (Institute for Molecular Medicine, FIMM, University of Helsinki).

In the Footsteps of Migrating Cancer Cells
18.11.2011, by Anja Mai
(Department of Biochemistry and Food Chemistry, University of Turku; Turku Centre for Biotechnology; Medical Biotechnology, VTT Technical Research Centre of Finland).
Supervised by Professor Johanna Ivaska (Department of Biochemistry and Food Chemistry, University of Turku; Turku Centre for Biotechnology; Medical Biotechnology, VTT Technical Research Centre of Finland)

Luminescence-based assay methods in drug discovery
28.10.2011, by Roope Huttunen
(Department of Cell Biology and Anatomy, University of Turku).
Supervised by Docent Juhani Soini (Laboratory of Biophysics, Department of Cell Biology and Anatomy, University of Turku and Turku University of Applied Sciences) and Docent Harri Härmä (Laboratory of Biophysics, Department of Cell Biology and Anatomy, University of Turku).

Potential of the Osteoclast’s Proton Pump as a Drug Target in Osteoporosis 19.8.2011, by Jonas Nyman
(Department of Cell Biology and Anatomy, University of Turku).
Supervised by Professor Kalervo Väänänen (Department of Cell Biology and Anatomy, University of Turku).

Alpha2-Adrenoceptors: structure and ligand binding properties at the molecular level
6.5.2011, by Jonne M. M. Laurila
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Professor Mika Scheinin (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Studies on [68]Ga-Based Agents for PET Imaging of Cancer and Inflammation 14.1.2011, by Tiina Ujula (Turku PET Centre and Department of Clinical Physiology and Nuclear Medicine, University of Turku).
Supervised by Adjunct Professor Anne Roivainen (Turku PET Centre and Turku Centre for Disease Modelling) and Professor Pirkko Härkönen (Department of Cell Biology and Anatomy, University of Turku).

BISPHOSPHONATE INHIBITION OF PROSTATE CANCER CELL INVASION, MIGRATION AND CYTOSKELETAL ORGANIZATION
11.12.2010, by Sanna S Virtanen
(Department of Cell Biology and Anatomy, University of Turku).
Supervised by Professor Pirkko Härkönen (Department of Cell Biology and Anatomy, University of Turku).

ATF3 and GIMAP Family Proteins 1 and 4 in Human T Helper Cell Differentiation 17.9.2010, by Sanna Filen (Turku Centre for Biotechnology, Åbo Akademi). Supervised by Professor Riitta Lahesmaa (Turku Centre for Biotechnology, University of Turku and Åbo Akademi).

New mechanisms regulating human Th1 and Th2 cell differentiation
2010, by Johanna Tahvanainen
(Department of Medical Biochemistry and Genetics, University of Turku).
Supervised by Professor Riitta Lahesmaa (Turku Centre for Biotechnology, University of Turku and Åbo Akademi).

The role of hydroxysteroid (17-beta) dehydrogenase 2, 7 and 12 enzymes in mouse development
2010, by Pia Rantakari (Department of Physiology, University of Turku). Supervised by Professor Matti Poutanen (Department of Physiology, University of Turku).

Molecular profiling of human endometrium and endometriosis
2010, by Kaisa Huhtinen (Department of Physiology, University of Turku). Supervised by Professor Matti Poutanen (Department of Physiology, University of Turku) and Docent Antti Perheentupa (Depatments of Physiology and Obstetrics & Gynecology, University of Turku).

IMAGING OF THE VULNERABLE ATHEROSCLEROTIC PLAQUE Pre-Clinical Evaluation of PET Tracers for Vascular Inflammation
2009, by Iina Laitinen (Turku PET Centre and Department of Clinical Physiology and Nuclear Medicine, University of Turku).
Supervised by Professor Juhani Knuuti (Turku PET Centre) and Adjunct Professor Anne Roivainen (Turku PET Centre and Turku Centre for Disease Modelling).

Genetic factors in the regulation of striatal and extrastriatal dopamine D2 receptor expression
2009, by Mika Hirvonen
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Professor Jarmo Hietala and Docent Ullamari Pesonen (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Neuropeptide Y at the cellular level – Studies on PreproNPY L7P Polymorphism and the Mitochondrial Form of NPY
2009, by Katja Kaipio
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Ullamari Pesonen (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Transgenic mice overexpressing neuropeptide Y: An experimental model of metabolic and cardiovascular diseases
2009, by Suvi Ruohonen
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Eriika Savontaus and Docent Ullamari Pesonen (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Vitamin D, Lipid Metabolism and Prostate Cancer 2009, by Jing-huan Wang
Department of Anatomy, University of Tampere).
Supervised by Professor Pentti Tuohimaa (Department of Anatomy, University of Tampere).

Design and Synthesis of Silent Information Regulator Human Type 2 (SIRT2) Inhibitors 2008, by Päivi Kiviranta
(Department of Pharmaceutical Chemistry, University of Kuopio).
Supervised by Ph.D. Erik Wallen (Division of Pharmaceutical Chemistry, University of Helsinki), Ph.D. Jukka Leppänen (Department of Pharmaceutical Chemistry, University of Kuopio), Professor Antti Poso, (Department of Pharmaceutical Chemistry, University of Kuopio) and Research Director Ph. D Antero Salminen, (Department of Neurobiology, University pf Kuopio).

An Experimental Model of Prostatic Inflammation for Drug Discovery
2008, by Jenni Bernoulli
(Department of Anatomy, University of Turku).
Supervised by Professor (Emeritus) Risto Santti (Department of Anatomy, University of Turku).

The central histaminergic neurons in vitro, and their neuroprotective role in excitotoxic cell death in the postnatal rat hippocampus
2008, by Tiina-Kaisa Kukko-Lukjanov
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Irma Holopainen (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

GABAa receptors in experimental models of epilepsy in the developing and adult brain
2007, by Hanna Lauren
(Department of Pharmacology, Drug Development and Therapeutics, University of Turku).
Supervised by Docent Irma Holopainen (Department of Pharmacology, Drug Development and Therapeutics, University of Turku).

Novel conditional mouse models for targeted kidney research – Emphasis on the analysis of the biological function of nephrin
2007, by Juuso Juhila, (University of Helsinki)

Transcriptional regulation of the hepatic cytochrome P450 2a5 gene
2007, by Satu Arpiainen,
(Department of Pharmacology and Toxicology, University of Oulu).
Supervised by Docent Jukka Hakkola, (Department of Pharmacology and Toxicology, University of Oulu).

Usefulness of Cerebrospinal Fluid Biomarkers in Diagnosis of Early Alzheimer’s Disease
2007, by Sanna-Kaisa Herukka
(Department of Neurology, University of Kuopio).
Supervised by Professor Tuula Pirttilä (Department of Neurology, Kuopio University Hospital) and Professor Heikki Tanila (Department of Neurology, University of Kuopio).

Estrogen Action in the Male Lower Urinary Tract and Prostate with a Special Reference to Estrogen Receptor Subtypes (ERα and ERβ)
2007, by Saija Savolainen
(Dept. of Anatomy and Functional Foods Forum, University of Turku).
Supervised by Professor Risto Santti and professor Sari Mäkelä (Dept. of Anatomy and Functional Foods Forum, University of Turku).

Regulation of Growth Factor Signaling by Vitamin D in Human Prostate Cancer Cells
2006, by Nadezda Nazarova
(Dept. of Anatomy, University of Tampere).
Supervised by Professor Pentti Tuohimaa (Dept. of Anatomy, University of Tampere).

*THE EFFECTS OF ANESTHESIA AND SEDATION ON EEG SPECTRAL ENTROPY AND REGIONAL CEREBRAL BLOOD FLOW
Positron Emission Tomography and EEG Studies on Healthy Male Subjects*
2006, by Anu Maksimow
(Turku PET Centre and the Department of Anesthesiology and Intensive Care, University of Turku).
Supervised by Professor Harry Scheinin and Docent Satu Jääskeläinen (Turku PET Centre and the Department of Anesthesiology and Intensive Care, University of Turku).

Effects of Estrogen and Selective Estrogen Receptor Modulators on the Rat Uterus
2006, by Huili Zheng
(Dept. of Anatomy, University of Turku).
Supervised by Professor Pirkko Härkönen (Dept. of Anatomy, University of Turku).

The Role of Osteocytes in Bone Metabolism Development of In Vitro Assays for Studying Cell Biology of Osteocyte
2005, by Guoliang Gu
(Dept. of Anatomy, University of Turku).
Supervised by Professor Kalervo Väänänen and Docent Teuvo Hentunen (Dept. of Anatomy, University of Turku).

*17β-HYDROXYSTEROID DEHYDROGENASES/17-KETOSTEROID REDUCTASES (17HSD/KSRs) IN PROSTATE CANCER
The role of 17HSD/KSR types 2, 5, and 7 in steroid hormone action and loss of heterozygosity at chromosome region 16q*
2005, by Päivi Härkönen
(Research Center for Molecular Endocrinology, University of Oulu).
Supervised by Professor Pirkko Vihko (Research Center for Molecular Endocrinology, University of Oulu).

Regulation of Dopamine Release in the Forebrain by Alpha2 Adrenoceptors and NMDA Glutamate Receptors – A Microdialysis Study
2005, by Jouni Ihalainen
(Dept. of Neurobiology, University of Kuopio).
Supervised by Professor Heikki Tanila (Dept. of Neurobiology, University of Kuopio).

CHARACTERIZATION OF G-PROTEIN-COUPLED PEPTIDE RECEPTOR ACTIVATION IN TRANSFECTED CELLS Identification of Superagonists at Specific Human neuropeptide FF and Human Somatostatin Receptor Subtypes
2005, by Mia Engström
(Juvantia Pharma Ltd., Turku and Dept. of Pharmacology and Clinical Pharmacology, University of Turku).
Supervised by Docent Juha-Matti Savola and Dr Siegfried Wurster (Juvantia Pharma Ltd., Turku and Dept. of Pharmacology and Clinical Pharmacology, University of Turku).

The roles of Stat4 and Stat6 during early stages of CD4+ T lymphocyte differentiation to Th1 and Th2 subsets
2004, by Zhi Chen (Turku Centre for Biotechnology).
Supervised by Professor Riitta Lahesmaa (Turku Centre for Biotechnology).

Involvement of a genetic variation in the human alpha2B-adrenoceptor in acute coronary events and hypertension
2003, by Amir Snapir
(Dept. of Pharmacology, University of Turku).
Supervised by Professor Mika Scheinin (Dept. of Pharmacology, University of Turku).

Hydroxymatairesinol from norway spruce (Picea abies), a novel enterolactone precursor with anticarcinogenic properties in experimental mammary carcinoma
2002, by Niina Saarinen
(Dept. of Anatomy, University of Turku).
Supervised by Professor Risto Santti (Dept. of Anatomy, University of Turku).

Hormone-related reversible urinary rhabdosphincter disorder in male laboratory rodents – possible clinical implications
2002, by Tomi Streng
(Dept. of Anatomy, University of Turku).
Supervised by Professor Risto Santti (Dept. of Anatomy, University of Turku).

Gene regulation in neuronal degeneration – role of mSin3 and YY1 factor
2002, by Pauliina Korhonen
(Dept. of Neurology, University of Kuopio).
Supervised by Professor Antero Salminen (Dept. of Neurology , University of Kuopio).

Gene expression profiles of human type 1 and type 2 T helper cells
2001, by Heli Hämäläinen
(Turku Centre for Biotechnology).
Supervised by Professor Riitta Lahesmaa (Turku Centre for Biotechnology).

The role of the septohippocampal cholinergic system in cognitive functions
2001, by Sami Ikonen
(Dept. of Neurobiology, University of Kuopio).
Supervised by Professor Heikki Tanila(Dept. of Neurobiology, University of Kuopio).

Effect of estrogen and selective estrogen receptor modulators (SERMs) on bone formation and experimental osteoporosis
1999, by Qiang Qu
(Dept. of Anatomy, University of Turku).
Supervised by Professor Pirkko Härkönen and Professor Kalervo Väänänen (Dept. of Anatomy, University of Turku).